Preferred Label : c-Met Inhibitor ABN401;
NCIt definition : An orally bioavailable, highly selective inhibitor of the oncoprotein c-Met (hepatocyte
growth factor receptor; HGFR), with potential antineoplastic activity. Upon oral administration,
ABN401 targets and binds to the c-Met protein, prevents c-Met phosphorylation and
disrupts c-Met-dependent signal transduction pathways. This may induce cell death
in tumor cells overexpressing c-Met protein or expressing constitutively activated
c-Met protein. c-Met protein is overexpressed or mutated in many tumor cell types
and plays key roles in tumor cell proliferation, survival, invasion, metastasis, and
tumor angiogenesis.;
Molecule name : ABN 401; ABN-401;
NCI Metathesaurus CUI : CL1383179;
Origin ID : C170765;
UMLS CUI : C5417816;
Semantic type(s)
- concept_is_in_subset
- has_target
