Preferred Label : Recombinant Bacterial Minicells VAX014;
NCIt synonyms : rBMCs VAX014; VAX-IP Minicells; VAX-IP;
NCIt definition : A population of recombinant bacterial minicells (rBMCs) engineered to express the
alpha3beta1 (a3b1) and alpha5beta1 (a5b1) integrin-targeting invasion and that contain
a bacterial protein toxin, perfringolysin O (PFO), with potential antineoplastic activity.
Upon intravesical administration, VAX014 selectively targets and binds to tumor cells
expressing un-ligated a3b1 and/or a5b1 integrins and delivers PFO, leading to destabilization
of tumor cell membranes and tumor cell lysis. By targeting un-ligated a3b1 and/or
a5b1 integrins, VAX014 selectively targets tumor cells over normal cells, with potentially
less adverse effects in comparison with first generation integrin-targeted therapies.;
Molecule name : VAX-014; VAX 014;
NCI Metathesaurus CUI : CL1383139;
Origin ID : C170742;
UMLS CUI : C5417806;
Semantic type(s)
- concept_is_in_subset
- has_target
