" /> Nelarabine - CISMeF





Preferred Label : Nelarabine;

NCIt synonyms : Compound 506U78; 2-Amino, 6-Methoxypurine Arabinoside; 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine;

NCIt related terms : 506U78; 2-Amino-6-methoxypurine arabinoside; Arranon;

NCIt definition : An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites.;

UNII : 60158CV180;

InChIKey : IXOXBSCIXZEQEQ-UHTZMRCNSA-N;

CAS number : 121032-29-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 121032-29-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Arranon;

Molecule name : 506U78; GW506U78;

Chemical formula : C11H15N5O5;

NSC code : 686673;

ChEBI ID : CHEBI:63612;

Codes from synonyms : CDR0000507537; CDR0000367460; NSC0686673; CDR0000046136; 349;

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Keyword's position in hierarchy(ies) : arborescence

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16/05/2024


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