Nelarabine - CISMeF

Preferred Label : Nelarabine;

NCIt synonyms : Compound 506U78; 2-Amino, 6-Methoxypurine Arabinoside; 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine;

NCIt related terms : 506U78; 2-Amino-6-methoxypurine arabinoside; Arranon;

NCIt definition : An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites.;

UNII : 60158CV180;

InChIKey : IXOXBSCIXZEQEQ-UHTZMRCNSA-N;

CAS number : 121032-29-9;

Drug name : Arranon;

Molecule name : 506U78; GW506U78;

Chemical formula : C11H15N5O5;

NSC code : 686673;

ChEBI ID : CHEBI:63612;

Codes from synonyms : CDR0000507537; CDR0000367460; NSC0686673; CDR0000046136; 349;

Details

Origin ID

C1704;

UMLS CUI

C0907349;

Automatic exact mappings (from CISMeF team)
- GW506U78 [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Nelarabine (substance) [SNOMED CT concept]
- Product containing nelarabine (medicinal product) [SNOMED CT concept]
- nelarabine [ATC Code]
- nelarabine [International Nonproprietary Name]
- nelarabine [MeSH Supplementary Concept]
- nelarabine [MeSH concept]
Validated automatic mappings to BTNT
- nelarabine [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
- Nucleoside Analogue Incorporation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Synthesis Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA [NCIt concept]
is_component_of_chemotherapy_regimen
- 506U78/Asparaginase/Daunorubicin/Methotrexate/Prednisone/Vincristine [NCIt concept]
- 506U78/Mercaptopurine/Methotrexate [NCIt concept]
- Asparaginase/Daunorubicin/Methotrexate/Nelarabine/Prednisone/Vincristine [NCIt concept]
- Mercaptopurine/Methotrexate/Nelarabine [NCIt concept]
- Nelarabine Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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