Ravoxertinib - CISMeF

Preferred Label : Ravoxertinib;

NCIt synonyms : ERK Inhibitor GDC-0994;

NCIt definition : An orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, ravoxertinib inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.;

UNII : R6AXV96CRH;

InChIKey : RZUOCXOYPYGSKL-GOSISDBHSA-N;

CAS number : 1453848-26-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1453848-26-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : GDC-0994;

NCI Metathesaurus CUI : CL1382601;

Details

Origin ID

C170364;

UMLS CUI

C5139665;

Currated CISMeF NLP mapping
- ravoxertinib [MeSH concept]
- ravoxertinib [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ravoxertinib [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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