Onapristone - CISMeF

Preferred Label : Onapristone;

NCIt definition : An orally bioavailable progesterone receptor (PR) antagonist, with potential antineoplastic activity. Upon oral administration, onapristone binds to the PR and inhibits both PR activation and the associated expression of PR-responsive genes. This may inhibit PR-mediated proliferative effects in cancer cells overexpressing PR. In addition, onapristone may downregulate cancer stem cell mobilization and block immune evasion. PR is expressed on certain cancer cell types and plays a key role in tumor cell proliferation and survival.;

UNII : H6H7G23O3N;

InChIKey : IEXUMDBQLIVNHZ-YOUGDJEHSA-N;

CAS number : 96346-61-1;

NCI Metathesaurus CUI : CL1382731;

Details

Origin ID

C170255;

UMLS CUI

C0069492;

Automatic exact mappings (from CISMeF team)
- onapristone [MeSH Supplementary Concept]
- onapristone [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- onapristone [MeSH Supplementary Concept]
- onapristone [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Progesterone Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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