NCIt definition : The hydrochloride salt form of olmutinib, an orally available small molecule, mutant-selective
inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic
activity. Olmutinib binds to and inhibits mutant forms of EGFR, thereby leading to
cell death of EGFR-expressing tumor cells. As this agent is selective towards mutant
forms of EGFR, its toxicity profile may be reduced as compared to non-selective EGFR
inhibitors which also inhibit the EGFR wild type form.;
Semantic type(s)