NCIt definition : An orally available small molecule, mutant-selective inhibitor of epidermal growth
factor receptor (EGFR) with potential antineoplastic activity. Olmutinib binds to
and inhibits mutant forms of EGFR, thereby leading to cell death of EGFR-expressing
tumor cells. As this agent is selective towards mutant forms of EGFR, its toxicity
profile may be reduced as compared to non-selective EGFR inhibitors which also inhibit
the EGFR wild type form.;