Olmutinib - CISMeF

Preferred Label : Olmutinib;

NCIt synonyms : 2-Propenamide, N-(3-((2-((4-(4-methyl-1-piperazinyl)phenyl)amino)thieno(3,2-d)pyrimidin-4-yl)oxy)phenyl)-;

NCIt definition : An orally available small molecule, mutant-selective inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Olmutinib binds to and inhibits mutant forms of EGFR, thereby leading to cell death of EGFR-expressing tumor cells. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced as compared to non-selective EGFR inhibitors which also inhibit the EGFR wild type form.;

UNII : CHL9B67L95;

InChIKey : FDMQDKQUTRLUBU-UHFFFAOYSA-N;

CAS number : 1353550-13-6;

Molecule name : HM61713; BI 1482694;

NCI Metathesaurus CUI : CL435909;

Details

Origin ID

C101791;

UMLS CUI

C4301624;

Automatic exact mappings (from CISMeF team)
- Olmutinib [ICD-11 Extension code]
- olmutinib [ATC Code]
CISMeF manual mappings
- olmutinib [MeSH concept]
Currated CISMeF NLP mapping
- olmutinib [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- olmutinib [MeSH Supplementary Concept]
- olmutinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Olmutinib Hydrochloride [NCIt concept]
has_target
- Activating EGFR Gene Mutation [NCIt concept]
- EGFR NP_005219.2:p.T790M [NCIt concept]
is_free_acid_or_base_form_of
- Olmutinib Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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