Nirsevimab - CISMeF

Preferred Label : Nirsevimab;

NCIt synonyms : Nirsevimab-alip;

NCIt definition : A Fc-engineered recombinant human immunoglobulin (Ig) G1 kappa monoclonal antibody against the fusion protein (F protein) of human respiratory syncytial virus (RSV), that can be used for prophylactic and protective purposes in RSV infections. Upon administration, nirsevimab targets and binds to the F1 and F2 subunits of the RSV fusion (F) protein, thereby locking the RSV F protein in the prefusion conformation and blocking viral entry into the host cell. This neutralizes the virus and prevents syncytia formation. This may prevent RSV and RSV-associated lower respiratory tract infection (LRTI) among infants and young children. RSV F protein, a small envelop glycoprotein, is required for cytopathic syncytia formation resulting from cell-to-cell fusion. It is necessary for viral infection and spreading. Nirsevimab has an extended half-life and one administration may therefore provide seasonal protection against RSV.;

UNII : VRN8S9CW5V;

CAS number : 1989556-22-0;

Drug name : Beyfortus;

Molecule name : MEDI8897;

NCI Metathesaurus CUI : CL1382696;

Origin ID

C170224;

UMLS CUI

C5418478;

Currated CISMeF NLP mapping
- Nirsevimab [SMS substance]
- nirsevimab [MeSH Supplementary Concept]
- nirsevimab [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- nirsevimab [MeSH Supplementary Concept]
- nirsevimab [ATC Code]
Validated automatic mappings to BTNT
- nirsevimab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

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