Preferred Label : Efgivanermin Alfa;
NCIt synonyms : TNFRSF18 Protein Stimulant MEDI1873; TNFRSF18 Agonist MEDI1873; GITR Agonist MEDI1873; GITR Stimulant MEDI1873;
NCIt definition : A homogenous hexameric agonist fusion protein composed of the extracellular domain
(ECD) of the T-cell costimulatory receptor human glucocorticoid-induced tumor necrosis
factor receptor (tumor necrosis factor superfamily, member 18; TNFRSF18; GITR) ligand
(GITRL) and an immunoglobulin (Ig) G1 Fc domain, with potential immunomodulating and
antineoplastic activities. Upon administration, efgivanermin alfa binds to and activates
GITR found on multiple types of T-cells, thereby inducing both the activation and
proliferation of tumor antigen-specific T effector cells. This abrogates the suppression
of T effector cells which is induced by inappropriately activated T regulatory cells
(Tregs), suppresses Tregs and decreases Treg tumor infiltration, and activates the
immune system to help eradicate tumor cells. GITR, a member of the TNF receptor superfamily,
is expressed on the surface of multiple types of immune cells, including Tregs, effector
T-cells, B-cells, dendritic cells (DCs) and natural killer (NK) cells.;
UNII : Y2R45V0JU8;
CAS number : 1807864-13-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1807864-13-6
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : MEDI 1873; MEDI1873;
NCI Metathesaurus CUI : CL1382432;
Origin ID : C169931;
UMLS CUI : C5418364;
Semantic type(s)
- concept_is_in_subset
- has_target
