" /> Abivertinib Maleate - CISMeF





Preferred Label : Abivertinib Maleate;

NCIt definition : The maleate salt form of abivertinib, an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, abivertinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of cancers, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.;

UNII : Y50131AMFJ;

InChIKey : QITOONQVTOGMOJ-IUJXYRIYSA-N;

CAS number : 1822357-78-7;

NCI Metathesaurus CUI : CL1382258;

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31/07/2025


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