Preferred Label : Abivertinib;
NCIt definition : An orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective
inhibitor, with potential antineoplastic activity. Upon oral administration, abivertinib
covalently binds to and inhibits the activity of mutant forms of EGFR, including the
drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms
of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated
tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of cancers,
plays a key role in tumor cell proliferation and tumor vascularization. As this agent
is selective towards mutant forms of EGFR, its toxicity profile may be reduced when
compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.;
UNII : CER0OPG92L;
InChIKey : UOFYSRZSLXWIQB-UHFFFAOYSA-N;
CAS number : 1557267-42-1;
Molecule name : AC 0010; AC-0010;
NCI Metathesaurus CUI : CL545072;
Origin ID : C147125;
UMLS CUI : C4687720;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
