Plasminogen Activator Inhibitor 2

Preferred Label : Plasminogen Activator Inhibitor 2;

NCIt synonyms : SERPINB2; Plasminogen Activator Inhibitor Type II; PLANH2; Placental Plasminogen Activator Inhibitor; Plasminogen Activator Inhibitor-2; Serine or Cysteine Proteinase Inhibitor Clade B Member 2; Urokinase Inhibitor; Monocyte Arg-Serpin; Serpin B2; PAI-2; Arginine-Serpin; PAI2;

NCIt definition : Plasminogen activator inhibitor 2 (415 aa, 47 kDa) is encoded by the human SERPINB2 gene. This protein plays a role in the modulation of both plasmin activation and apoptosis.;

NCIt note : Plasminogen Activator Inhibitor-2 is a member of the serpin superfamily that inhibits both tissue-type and urokinase-type plasminogen activators. PAI2 (monocyte Arg-serpin) also belongs to the serine protease subfamily in which target specificity is determined by an Arg residue at its reactive center: Met/Val for elastase, Leu for kinase, and Arg for thrombin. PAI2 is thought to regulate plasminogen activation in extravascular compartments and high levels are found in keratinocytes, monocytes, and the trophoblast. (from OMIM 173390);

Details

Origin ID

C16948;

UMLS CUI

C3887675;

Currated CISMeF NLP mapping
- Plasminogen activator inhibitor 2 [LOINC component]
- Plasminogen activator inhibitor-2 (substance) [SNOMED CT concept]
- plasminogen activator inhibitor 2 [MeSH Descriptor]
- plasminogen activator inhibitor 2 [MeSH concept]
- plasminogen activator inhibitor-2 [SNOMED Notion]
- plasminogen activator inhibitors, placental [MeSH concept]
- urokinase inhibitor [MeSH concept]
- urokinase inhibitor [MeSH Supplementary Concept]
OMIM relation
- Serpin peptidase inhibitor, clade b (ovalbumin), member 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Inhibitor Gene [NCIt concept]
- Proteinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SERPINB2 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Serpin [NCIt concept]
gene_product_has_chemical_classification
- Serpin [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Enzyme Inhibition [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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