NCIt definition : An immunotherapeutic agent that targets both CD19 and 4-1BB (CD137; tumor necrosis
factor receptor superfamily member 9; TNFRSF9), with potential immunostimulatory and
antineoplastic activity. Upon administration, ensomafusp alfa simultaneously binds
to CD19 and 4-1BB, thereby crosslinking CD19 and 4-1BB positive cells. This triggers,
through the 4-1BB ligand, the proliferation and activation of natural killer cells
(NKs) and T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated
immune response against CD19-expressing tumor cells. 4-1BB, a surface glycoprotein
of the tumor necrosis factor receptor superfamily (TNFRSF), is an inducible costimulatory
receptor that plays a key role in T-cell proliferation, survival and cytolytic activity.;
UNII : U4T9GD9GR9;
CAS number : 2417199-08-5;
Molecule name : RO 7227166; RO-7227166; RG 6076; RG-6076;
False automatic mappings