Preferred Label : Pegylated SN-38 Conjugate PLX038;
NCIt synonyms : Pegylated SN-38 PLX038;
NCIt definition : A pegylated conjugate of SN-38 (7-ethyl-10-hydroxy-camptothecin), a biologically active
metabolite of the prodrug irinotecan, with potential antineoplastic activity. Upon
administration, the proprietary linker slowly releases SN-38 from the pegylated SN-38
conjugate PLX038. SN-38 binds to and inhibits topoisomerase I by stabilizing the cleavable
complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA
replication, and apoptosis. Compared with irinotecan, this formulation allows higher
accumulation in solid tumors due to its nanoparticle size and long half-life.;
Molecule name : PLX-038; PLX 038;
NCI Metathesaurus CUI : CL972311;
Origin ID : C167334;
UMLS CUI : C5238470;
Semantic type(s)
- concept_is_in_subset
- has_target
