Preferred Label : Zirconium Zr 89-DFO-SC16.56;
NCIt synonyms : 89Zr-DFO-SC16.56;
NCIt definition : A radioimmunoconjugate composed of SC16.56, a monoclonal antibody directed against
the tumor-associated antigen (TAA) delta-like protein 3 (DLL3; delta like canonical
notch ligand 3; drosophila delta homolog 3; delta3; delta-like 3; SCDO1), and linked,
via the chelator desferrioxamine (DFO), to the radioisotope zirconium Zr 89 (Zr89),
with potential diagnostic properties upon positron emission tomography (PET) imaging.
Upon administration of zirconium Zr 89-DFO-SC16.56, the monoclonal antibody moiety
specifically targets and binds to DLL3. Upon binding, the radioisotope moiety is detected
using PET, thereby allowing the imaging and quantification of DLL3-expressing tumor
cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell
types. It plays a key role in embryonic development and in tumor initiation and proliferation.;
NCI Metathesaurus CUI : CL972456;
Origin ID : C167231;
UMLS CUI : C5238383;
Semantic type(s)
- concept_is_in_subset
- has_target
