Preferred Label : Sunvozertinib;
NCIt synonyms : EGFR/HER2 Inhibitor DZD9008;
NCIt definition : An orally available, irreversible, dual kinase inhibitor of epidermal growth factor
receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) that shows similar
activity against certain activating mutations, including exon 20 insertions (exon20ins),
with potential antineoplastic activity. Upon oral administration,sunvozertinib binds
to and inhibits EGFR and HER2, which may result in the inhibition of tumor growth
and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. EGFR and HER2
are receptor tyrosine kinases that play major roles in tumor cell proliferation and
tumor vascularization. In contrast to other agents active against exon20ins mutations,
sunvozertinib appears to be more selective against mutated EGFR than wild-type (wt)
EGFR. This may lessen wtEGFR-related dose-limiting toxicity and may allow for the
administration of the desired therapeutic dose of sunvozertinib.;
UNII : L1Q2K5JYO8;
CAS number : 2370013-12-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2370013-12-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : DZD-9008; DZD 9008;
NCI Metathesaurus CUI : CL972432;
Origin ID : C167205;
UMLS CUI : C5667199;
Semantic type(s)
- concept_is_in_subset
- has_target
