" /> Indium In-111 Pentetreotide - CISMeF





Preferred Label : Indium In-111 Pentetreotide;

NCIt synonyms : In 111 Pentetreotide; Indium In 111-Pentetreotide; Indium-In-111-Pentetreotide; Indium-In 111 Pentetreotide; Indium In 111 Pentetreotide; Indium-111-DTPA-D-Phe-1-octreotide;

NCIt definition : An indium 111 radioconjugate of pentetreotide, the diethylenetriaminopentaacetic (DTPA) conjugate of the human hormone somatostatin peptide analogue (octreotide), used for radioimaging neuroendocrine tumor cells. The pentetreotide moiety of indium In 111 pentetreotide binds to somatostatin receptors (SSTRs), especially type 2 receptors, present on the cell membranes of many types of neuroendocrine tumor cells. Upon binding and internalization, this radioconjugate allows for specific imaging of neuroendocrine tumors that overexpress somatostatin using scintigraphic imaging techniques. In addition, high dose indium In 111 pentetreotide may specifically deliver a cytotoxic dose of gamma radiation to SSTR-positive cells thereby killing SSTR-expressing tumor cells.;

Alternative definition : NCI-GLOSS: An anticancer drug belonging to a family of drugs called radiopharmaceuticals.;

UNII : M312JJ6Z32;

InChIKey : ONJXCGCIKIYAPL-KUUVKUFMSA-K;

CAS number : 139096-04-1;

Drug name : OctreoScan;

Chemical formula : C63H83N13O19S2.H.In;

Codes from synonyms : CDR0000046072;

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03/05/2025


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