Preferred Label : Daclatasvir Dihydrochloride;
NCIt related terms : DACLATASVIR HYDROCHLORIDE;
NCIt definition : The dihydrochloride salt form of daclatasvir, an orally available inhibitor of the
hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with
potential activity against HCV. Although the exact mechanism of action of daclatasvir
has yet to be fully determined, this agent, upon oral administration and after intracellular
uptake, appears to bind to domain I of the NS5A protein. This inhibits the activity
of the NS5A protein and results in the disruption of the viral RNA replication complex,
blockage of viral HCV RNA production, and inhibition of viral replication. NS5A, a
zinc-binding and proline-rich hydrophilic phosphoprotein, plays a crucial role in
HCV RNA replication. HCV is a small, enveloped, single-stranded RNA virus belonging
to the Flaviviridae family.;
UNII : 50ZO25C11D;
InChIKey : BVZLLUDATICXCI-JMSCDMLISA-N;
CAS number : 1009119-65-6;
NCI Metathesaurus CUI : CL971792;
Origin ID : C166798;
UMLS CUI : C3892852;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
