Preferred Label : Daclatasvir;
NCIt synonyms : Carbamic Acid, N,N'-((1,1'-biphenyl)-4,4'-diylbis(1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl((1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl)))bis-,
C,C'-dimethyl Ester; DCV;
NCIt definition : An orally available inhibitor of the hepatitis C virus (HCV) non-structural protein
5A (NS5A) replication complex, with potential activity against HCV. Although the exact
mechanism of action of daclatasvir has yet to be fully determined, this agent, upon
oral administration and after intracellular uptake, appears to bind to domain I of
the NS5A protein. This inhibits the activity of the NS5A protein and results in the
disruption of the viral RNA replication complex, blockage of viral HCV RNA production,
and inhibition of viral replication. NS5A, a zinc-binding and proline-rich hydrophilic
phosphoprotein, plays a crucial role in HCV RNA replication. HCV is a small, enveloped,
single-stranded RNA virus belonging to the Flaviviridae family.;
UNII : LI2427F9CI;
InChIKey : FKRSSPOQAMALKA-CUPIEXAXSA-N;
CAS number : 1009119-64-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1009119-64-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : BMS-790052;
Origin ID : C114981;
UMLS CUI : C3252090;
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset