NCIt definition : A covalent conjugate of human recombinant interferon (IFN) lambda-1 (IFN-L1; IL-29),
a type III IFN, and a linear polyethylene glycol (PEG) chain, with antiviral and immunomodulating
activities. Upon administration, peginterferon lambda-1A targets and binds to type
III IFN receptors, which activates the JAK-STAT signaling cascade and upregulates
IFN-stimulated genes (ISGs), leading to cell-mediated immune responses. The PEG chain
of peginterferon lambda-1A lowers the clearance of interferon lambda-1A, thereby extending
the duration of its therapeutic effects. Endogenous IFN-L1 is produced following viral
infection and it plays a key role in innate immune response against the viral pathogens.;
UNII : 0T0250N43U;
CAS number : 914617-98-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 914617-98-4
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