Peginterferon Lambda-1A

Preferred Label : Peginterferon Lambda-1A;

NCIt synonyms : Peginterferon Lambda; Pegylated IFN Lambda-1a; Pegylated Interferon Lambda-1a;

NCIt definition : A covalent conjugate of human recombinant interferon (IFN) lambda-1 (IFN-L1; IL-29), a type III IFN, and a linear polyethylene glycol (PEG) chain, with antiviral and immunomodulating activities. Upon administration, peginterferon lambda-1A targets and binds to type III IFN receptors, which activates the JAK-STAT signaling cascade and upregulates IFN-stimulated genes (ISGs), leading to cell-mediated immune responses. The PEG chain of peginterferon lambda-1A lowers the clearance of interferon lambda-1A, thereby extending the duration of its therapeutic effects. Endogenous IFN-L1 is produced following viral infection and it plays a key role in innate immune response against the viral pathogens.;

UNII : 0T0250N43U;

CAS number : 914617-98-4;

NCI Metathesaurus CUI : CL971686;

Details

Origin ID

C166435;

UMLS CUI

C4043002;

Currated CISMeF NLP mapping
- peginterferon lambda-1a [MeSH concept]
- peginterferon lambda-1a [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- peginterferon lambda-1a [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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