Preferred Label : Sacituzumab Tirumotecan;
NCIt synonyms : ADC SKB264; Anti-TROP2 Antibody-drug Conjugate MK-2870; ADC MK-2870; Anti-TROP2 Antibody-drug Conjugate SKB264;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody against tumor-associated
antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal
transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) conjugated to an as of yet undisclosed
toxin, with potential antineoplastic activity. Upon administration sacituzumab tirumotecan,
the anti-TROP2 antibody targets and binds to TROP2 expressed on tumor cells. Upon
cellular uptake, the undisclosed toxin exerts, through an as of yet not disclosed
mechanism of action, its cytotoxic effect. This inhibits tumor cell proliferation
of TROP2-expressing tumor cells. TROP2 is a transmembrane protein overexpressed in
various tumors while its expression is low and/or restricted in normal, healthy tissues;
its expression is associated with enhanced tumor aggressiveness, metastasis, drug
resistance and increased tumor cell survival.;
UNII : 3DV5TD1VL3;
CAS number : 2768350-77-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2768350-77-0
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : SKB 264; SKB-264; MK 2870; MK-2870;
NCI Metathesaurus CUI : CL971661;
Origin ID : C166409;
UMLS CUI : C5237963;
Semantic type(s)
- concept_is_in_subset
- has_target
