Preferred Label : Parsaclisib Hydrochloride;
NCIt synonyms : INCB 50465 Hydrochloride; (4R)-4-(3-((1S)-1-(4-amino-3-methyl-1h-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-onehydrochloric
Acid (1:1); 2-Pyrrolidinone, 4-(3-((1S)-1-(4-amino-3-methyl-1h-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)-,
Hydrochloride (1:1), (4R)-; INCB050465 Hydrochloride;
NCIt definition : The hydrochloride salt form of parsaclisib, an inhibitor of the delta isoform of phosphoinositide-3
kinase (PI3K) with potential antineoplastic activity. Parsaclisib inhibits the delta
isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This
both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor
cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic
disease and cell lineages. The targeted inhibition of PI3K-delta is designed to preserve
PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed
in cancer cells, plays a crucial role in tumor cell regulation and survival.;
UNII : S0GJ8VM4P9;
InChIKey : TWHUONANZMKBKX-ACMTZBLWSA-N;
CAS number : 1995889-48-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1995889-48-9
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G-SRS /a ;
NCI Metathesaurus CUI : CL971639;
Origin ID : C166387;
UMLS CUI : C5237946;
Semantic type(s)
- concept_is_in_subset
- has_target
