Parsaclisib - CISMeF

Preferred Label : Parsaclisib;

NCIt synonyms : (4R)-4-(3-((1S)-1-(4-Amino-3-methyl-1H-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one; WHO 10589;

NCIt definition : An inhibitor of the delta isoform of phosphoinositide-3 kinase (PI3K) with potential antineoplastic activity. Parsaclisib inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic disease and cell lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.;

UNII : OS7097575K;

InChIKey : ZQPDJCIXJHUERQ-QWRGUYRKSA-N;

CAS number : 1426698-88-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1426698-88-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : INCB050465; INCB-50465; INCB 50465; IBI376;

NCI Metathesaurus CUI : CL458228;

Details

Origin ID

C113434;

UMLS CUI

C5139756;

Automatic exact mappings (from CISMeF team)
- (4R)-4-(3-((1S)-1-(4-amino-3-methyl-1H-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one [MeSH concept]
Currated CISMeF NLP mapping
- parsaclisib [MeSH Supplementary Concept]
- parsaclisib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- parsaclisib [MeSH Supplementary Concept]
- parsaclisib [ATC Code]
Validated automatic mappings to BTNT
- parsaclisib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]

Keyword's position in hierarchy(ies) :

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