Preferred Label : Ifebemtinib;
NCIt synonyms : PTK2 Inhibitor IN10018; FAK1 Inhibitor IN10018; Protein Tyrosine Kinase 2 Inhibitor BI 853520; Protein Tyrosine Kinase 2 Inhibitor IN10018;
NCIt definition : An orally bioavailable inhibitor of the non-receptor, cytoplasmic tyrosine kinase
protein tyrosine kinase 2 (focal adhesion kinase 1; FAK1; FAK: PTK2) with potential
antineoplastic activity. Upon oral administration, ifebemtinib targets and inhibits,
in an adenosine triphosphate (ATP)-competitive manner, PTK2. This prevents PTK2-mediated
downstream signaling and inhibits migration, proliferation, invasion, and survival
in PTK2-overexpressing tumor cells. The cytoplasmic tyrosine kinase PTK2, a signal
transducer for integrins overexpressed in various tumor cell types, is involved in
tumor cell invasion, migration and proliferation.;
UNII : C57O858DKU;
CAS number : 1227948-82-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1227948-82-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : BI 853520; BI-853520; IN 10018; IN-10018;
NCI Metathesaurus CUI : CL979217;
Origin ID : C166122;
UMLS CUI : C5237721;
Semantic type(s)
- concept_is_in_subset
- has_target
