NCIt definition : An orally bioavailable protein-protein interaction (PPI) inhibitor of the menin-mixed
lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) proteins, with potential
antineoplastic activity. Upon oral administration, revumenib targets and binds to
the nuclear protein menin, thereby preventing the interaction between the two proteins
menin and MLL and the formation of the menin-MLL complex. This reduces the expression
of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged
leukemic cells. The menin-MLL complex plays a key role in the survival, growth, transformation
and proliferation of certain kinds of leukemia cells.;
UNII : LZ0M43NNF2;
CAS number : 2169919-21-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2169919-21-3
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