Preferred Label : Indium In 111-DOTA-h11B6;
NCIt synonyms : Indium-111 Radiolabeled h11B6; 111In-DOTA-h11B6;
NCIt definition : A radioimmunoconjugate containing the recombinant immunoglobulin G1 (IgG1) kappa humanized
monoclonal antibody h11B6 that targets human kallikrein-2 (HK2) conjugated with the
bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid
(DOTA) and labeled with the radioisotope indium In 111, with potential use as an imaging
agent. Upon administration of indium In 111-DOTA-h11B6, the h11B6 moiety targets and
binds to HK2. Upon binding and radioimaging, HK2-expressing tumor cells can be visualized
and the binding of h11B6 can be assessed. HK2 is overexpressed on a variety of cancer
cells.;
NCI Metathesaurus CUI : CL978950;
Origin ID : C165647;
UMLS CUI : C5237339;
Semantic type(s)
- concept_is_in_subset
- has_target
