Preferred Label : Alvocidib Prodrug TP-1287;
NCIt synonyms : Alvocidib Phosphate; Alvocidib Phosphate TP-1287;
NCIt related terms : TP-1287;
NCIt definition : An orally bioavailable, highly soluble phosphate prodrug of alvocidib, a potent inhibitor
of cyclin-dependent kinase-9 (CDK9), with potential antineoplastic activity. Upon
administration of the phosphate prodrug TP-1287, the prodrug is enzymatically cleaved
at the tumor site and the active moiety alvocidib is released. Alvocidib targets and
binds to CDK9, thereby reducing the expression of CDK9 target genes such as the anti-apoptotic
protein MCL-1, and inducing G1 cell cycle arrest and apoptosis in CDK9-overexpressing
cancer cells.;
UNII : 7MPP85IIJ3;
CAS number : 2044686-42-0;
Molecule name : TP 1287; TP-1287;
NCI Metathesaurus CUI : CL978685;
Origin ID : C165555;
UMLS CUI : C5237264;
Semantic type(s)
- concept_is_in_subset
- has_target
