NCIt definition : A cancer vaccine consisting of ALVAC, a highly attenuated poxvirus strain derived
from the canarypox virus, encoding for the tumor associated antigen (TAA) carcinoembryonic
antigen (CEA), with potential antineoplastic activity. Upon administration, ALVAC-CEA
vaccine expresses CEA and may stimulate a host immune response against tumor cells
expressing CEA. This may result in the inhibition of tumor growth and/or metastasis.
CEA is overexpressed in a variety of tumor cell types.;
Alternative definition : NCI-GLOSS: A cancer vaccine made with a form of the canarypox virus that does not
cause disease in people. It is being studied in the treatment of some kinds of cancer.
The virus is changed in the laboratory to make a protein called carcinoembryonic antigen
(CEA), which is a tumor marker. ALVAC-CEA vaccine may help the immune system find
and kill cancer cells that make CEA.;