Preferred Label : Ziftomenib;
NCIt synonyms : Menin-MLL Inhibitor KO-539; Menin-Mixed Lineage Leukemia Protein-Protein Interaction Inhibitor KO 539; Menin-KMT2A Inhibitor KO 539; Menin-MLL Interaction Inhibitor KO 539;
NCIt definition : An orally bioavailable inhibitor of the menin-mixed lineage leukemia (MLL; myeloid/lymphoid
leukemia; KMT2A) fusion protein, with potential antineoplastic activity. Upon oral
administration, ziftomenib prevents the interaction between the two proteins menin
and MLL, and thus the formation of the menin-MLL complex. This reduces the expression
of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged
leukemic cells. The menin-MLL complex plays a key role in the survival, growth and
proliferation of certain kinds of leukemia cells.;
UNII : 4MOD1F4ENC;
CAS number : 2134675-36-6;
Molecule name : KO 539; KO-539;
NCI Metathesaurus CUI : CL977514;
Origin ID : C164227;
UMLS CUI : C5667195;
Semantic type(s)
- concept_is_in_subset
- has_target
