Preferred Label : Cedazuridine;
NCIt synonyms : (4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine; CDA Inhibitor E7727; Uridine, 2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydro-, (4R);
NCIt definition : An orally available synthetic nucleoside analog derived from tetrahydrouridine (THU)
and cytidine deaminase inhibitor (CDAi), that can potentially be used to prevent the
breakdown of cytidines. Upon oral administration, cedazuridine binds to and inhibits
CDA, an enzyme primarily found in the gastrointestinal (GI) tract and liver that catalyzes
the deamination of cytidine and cytidine analogs. Given in combination with a cytidine,
such as the antineoplastic hypomethylating agent decitabine, it specifically prevents
its breakdown and increases its bioavailability and efficacy. In addition, this allows
for lower doses of decitabine to be administered, which results in decreased decitabine-associated
GI toxicity.;
UNII : 39IS23Q1EW;
InChIKey : VUDZSIYXZUYWSC-DBRKOABJSA-N;
CAS number : 1141397-80-9;
Molecule name : E7727;
NCI Metathesaurus CUI : CL977331;
Origin ID : C164146;
UMLS CUI : C5226860;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
