Preferred Label : Alpha-Conotoxin GIA;
NCIt related terms : Alpha-GIA;
NCIt definition : A 15-amino acid alpha-conotoxin isolated from the venom of the cone snail Conus geographus
that is a competitive antagonist of the muscle-type nicotinic acetylcholine receptors,
blocking synaptic transmission at the neuromuscular junction. Alpha-conotoxins are
identified by a characteristic arrangement of four-cysteine residues (-CC-C-C-) and
disulfide bonding of Cys1-Cys3 and Cys2-Cys4. Alpha-conotoxin GIA is identical in
sequence to the neurotoxin alpha-conotoxin GI except for the presence of additional
residues of glycine and lysine at the carboxyl terminus.;
Alternative definition : CDISC: The biotoxin alpha-conotoxin GIA.;
NCI Metathesaurus CUI : CL976905;
Origin ID : C163583;
UMLS CUI : C5235581;
Semantic type(s)
- concept_is_in_subset
