NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the negative
immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1;
CD279), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration,rulonilimab targets, binds to and inhibits PD-1 and its downstream
signaling pathways. This may restore immune function through the activation of T-cells
and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein
in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune
checkpoint that negatively regulates T-cell activation and effector function when
activated by its ligands programmed cell death-1 ligand 1 (PD-L1; B7-H1; CD274) and
2 (PD-L2); it plays an important role in tumor evasion from host immunity.;
Semantic type(s)