Preferred Label : Oncolytic HSV-1 C134;
NCIt synonyms : C134-HSV-1; oHSV C134; IRS-1 HSV C134;
NCIt definition : A neurovirulent, oncolytic second-generation, replication-competent, recombinant and
genetically-engineered herpes simplex virus type 1 (HSV-1) where the gene for ICP34.5
has been deleted and the gene encoding the human cytomegalovirus (HCMV), protein kinase
R (PKR) evasion protein IRS1, with potential oncolytic and immunostimulating activities.
Upon intratumoral administration, oncolytic HSV-1 C134 specifically infects and replicates
within the rapidly dividing, glioma cells, thereby directly lysing tumor cells. The
released virus particles, in turn, infect and replicate in neighboring tumor cells,
thereby further killing tumor cells. Tumor antigens released from the lysed tumor
cells also activate the immune system to induce a tumor-specific systemic immune and
cytotoxic T-lymphocyte (CTL) response, thereby killing nearby non-infected tumor cells.
Deletion of the gene encoding for ICP34.5 imparts tumor selectivity by preventing
replication in healthy cells. IRS1 expression allows the virus to replicate within
tumors but limits viral spread.;
Molecule name : C 134; C-134;
NCI Metathesaurus CUI : CL971027;
Origin ID : C162635;
UMLS CUI : C5206709;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
https://campus.neurochirurgie.fr/article1780.html
2024
France
educational course
Neurosurgical Procedure
chronic pain
Refractory
Neurosurgery
Chronic Pain
pain, intractable
Oncolytic HSV-1 C134
neurosurgery
neurosurgery
chronic pain
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