Preferred Label : Verzistobart;
NCIt synonyms : Anti-TIM-3 Monoclonal Antibody INCAGN02390;
NCIt definition : A fully human Fc-engineered immunoglobulin G1 kappa (IgG1kappa) antibody directed
against the inhibitory T-cell receptor T-cell immunoglobulin and mucin domain-containing
protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor 2; HAVCR2), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, verzistobart
forms a high-affinity interaction with TIM-3 expressed on certain T-cells, thereby
preventing the engagement of TIM-3 by its ligands, phosphatidylserine (PtdSer) and
galectin-9. This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes
and enhances cytotoxic T-cell-mediated tumor cell lysis, which results in a reduction
in tumor cell proliferation. Additionally, INCAGN02390 elicits TIM-3 receptor internalization,
potentially preventing interactions with other ligands.TIM-3, a transmembrane protein
and immune checkpoint receptor expressed on certain lymphocytes, including tumor infiltrating
lymphocytes (TILs), is associated with tumor-mediated immune suppression.;
UNII : KAC8QY6TMN;
CAS number : 2649466-18-0;
Molecule name : INCAGN-02390; INCAGN 02390;
NCI Metathesaurus CUI : CL971021;
Origin ID : C162625;
UMLS CUI : C5854841;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
