Preferred Label : Luminespib Mesylate;
NCIt synonyms : Luminespib Mesilate; Luminespib Mesylate Hydrate;
NCIt definition : The mesylate salt of luminespib, a derivative of 4,5-diarylisoxazole and a third-generation
heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Upon
administration, luminespib binds with high affinity to and inhibits Hsp90, resulting
in the proteasomal degradation of oncogenic client proteins; the inhibition of cell
proliferation; and the elevation of heat shock protein 72 (Hsp72) in a wide range
of human tumor cell lines. Hsp90, a 90 kDa molecular chaperone, plays a key role in
the conformational maturation, stability and function of other substrate or client
proteins within the cell, many of which are involved in signal transduction, cell
cycle regulation and apoptosis, including kinases, transcription factors and hormone
receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used
as a surrogate marker for Hsp90 inhibition.;
UNII : 6R0MAC137G;
InChIKey : TUURDQPZDIZCLK-UHFFFAOYSA-N;
CAS number : 1051919-26-6;
Molecule name : NVP-AUY922-AGB;
NCI Metathesaurus CUI : CL971084;
Origin ID : C162567;
UMLS CUI : C5206651;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
