Puquitinib Mesylate

Preferred Label : Puquitinib Mesylate;

NCIt definition : The mesylate salt of puquitinib, an orally available selective inhibitor of the delta form of phosphatidylinositol 3-kinase (PI3-kinase subunit delta; PI3K-delta; PI3Kdelta), with potential antineoplastic activity. Upon oral administration, puquitinib selectively binds to the ATP-binding pocket of PI3K-delta and prevents the activation of the PI3K/AKT signaling pathway. This decreases proliferation of and induces cell death in PI3K-delta over-expressing tumor cells. PI3K-delta also plays a key role in the B-cell receptor (BCR) signaling pathway and the proliferation of certain hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells, thereby minimizing serious side effects.;

UNII : Z4NA6BNF2L;

InChIKey : XWHARLVGMNPKNZ-UHFFFAOYSA-N;

CAS number : 1018818-41-1;

Molecule name : XC-302 Anhydrous;

NCI Metathesaurus CUI : CL971077;

Details

Origin ID

C162556;

UMLS CUI

C4310253;

Currated CISMeF NLP mapping
- puquitinib mesylate [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]

Keyword's position in hierarchy(ies) :

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