NCIt definition : An orally available selective inhibitor of the delta form of phosphatidylinositol
3-kinase (PI3-kinase subunit delta; PI3K-delta; PI3Kdelta), with potential antineoplastic
activity. Upon oral administration, puquitinib selectively binds to the ATP-binding
pocket of PI3K-delta and prevents the activation of the PI3K/AKT signaling pathway.
This decreases proliferation of and induces cell death in PI3K-delta over-expressing
tumor cells. PI3K-delta also plays a key role in the B-cell receptor (BCR) signaling
pathway and the proliferation of certain hematologic cancer cells. The targeted inhibition
of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells,
thereby minimizing serious side effects.;
UNII : WFG29AB872;
InChIKey : QUTFBURLXCODBH-UHFFFAOYSA-N;
CAS number : 916890-10-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 916890-10-3
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