Src Kinase Inhibitor AP 23846

Preferred Label : Src Kinase Inhibitor AP 23846;

NCIt definition : A novel small molecule Src family kinase inhibitor with potential antiangiogenic activity. Upon administration, Src kinase inhibitor AP23846 selectively binds to and stabilizes an inactive ATP-binding site conformation leading to reduced Src kinase activity. This may reduce the production of pro-angiogenic factors, vascular endothelial growth factor (VEGF) and interleukin (IL)-8. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation, survival, migration, invasion and angiogenesis.;

CAS number : 878654-51-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 878654-51-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AP-23846; AP 23846;

NCI Metathesaurus CUI : CL971115;

Details

Origin ID

C162533;

UMLS CUI

C1702770;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AP23846 [MeSH Supplementary Concept]
- AP23846 [MeSH concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]

Keyword's position in hierarchy(ies) :

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