Preferred Label : Recombinant Human Plasminogen Kringle 5 Domain ABT 828;
NCIt synonyms : rhK5;
NCIt definition : A recombinant human plasminogen kringle 5 domain with potential antiangiogenic and
antineoplastic activities. Upon administration, recombinant human plasminogen kringle
5 domain ABT 828 may promote caspase activity and apoptosis in proliferating endothelial
cells, thereby inhibiting migration. Kringle 5 (K5), an internal proteolytic fragment
of plasminogen specifically inhibits endothelial cell growth via its interaction with
endothelial cell surface ATP synthase, which sequentially triggers the activation
of caspases -8, -9, and -3.;
Molecule name : ABT 828; ABT-828;
NCI Metathesaurus CUI : CL971108;
Origin ID : C162524;
UMLS CUI : C5206622;
Semantic type(s)
- concept_is_in_subset
