Src Kinase Inhibitor M475271

Preferred Label : Src Kinase Inhibitor M475271;

NCIt synonyms : 4-Quinazolinamine, N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-; N-(2-Chloro-5-methoxyphenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine;

NCIt related terms : M-475271;

NCIt definition : An inhibitor of Src tyrosine kinase, with potential antineoplastic activity. Upon administration, Src kinase inhibitor M-475271 targets and binds to Src kinase. This inhibits Src-mediated signaling and the proliferation of tumor cells overexpressing Src. Src tyrosine kinase, a non-receptor tyrosine kinase upregulated in many tumor cell types, plays an important role in tumor cell proliferation, motility, invasiveness and survival.;

UNII : 0361Z8214O;

InChIKey : WPOXAFXHRJYEIC-UHFFFAOYSA-N;

CAS number : 476159-98-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 476159-98-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : M-475271; AZM 475271; AZM-475271; M 475271;

NCI Metathesaurus CUI : CL970844;

Details

Origin ID

C162339;

UMLS CUI

C1608746;

Automatic exact mappings (from CISMeF team)
- 4-quinazolinamine, N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-((1-methyl-4-piperidinyl) methoxy) [MeSH concept]
- 4-quinazolinamine, N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-((1-methyl-4-piperidinyl) methoxy) [MeSH Supplementary Concept]
- N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- M475271 [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]

Keyword's position in hierarchy(ies) :

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