Preferred Label : Anti-HER2 Bispecific Antibody-drug Conjugate ZW49;
NCIt synonyms : Anti-HER2 Bispecific ADC ZW49; ADC ZW49;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a bispecific monoclonal antibody (ZW25)
directed against two different epitopes of the tumor-associated antigen (TAA) human
epidermal growth factor receptor 2 (HER2, receptor tyrosine-protein kinase erbB-2)
linked to an as of yet undisclosed cytotoxic payload, with potential antineoplastic
activity. Upon intravenous administration, anti-HER2 bispecific ADC ZW49 targets and
binds to HER2 expressed on tumor cells. Following receptor internalization, the cytotoxic
payload is released and induces tumor cell death through an as of yet unknown mechanism
of action. Additionally, binding of HER2 may inhibit HER2 activation, HER2 signaling
and HER2-mediated tumor cell growth. HER2, a tyrosine kinase receptor, is overexpressed
by many cancer cell types.;
Molecule name : ZW-49;
NCI Metathesaurus CUI : CL970593;
Origin ID : C162115;
UMLS CUI : C5206340;
Semantic type(s)
- concept_is_in_subset
- has_target
