Preferred Label : ARC Fusion Protein SL-279252;
NCIt synonyms : PD1-Fc-OX40L ARC Fusion Protein; Agonist Redirected Checkpoint Fusion Protein SL-279252;
NCIt definition : An agonist redirected checkpoint (ARC) fusion protein consisting of the extracellular
domains of human programmed cell death 1 (PD-1; PDCD1; CD279) and tumor necrosis factor
ligand superfamily member 4 (TNFSF4; OX40 ligand; OX40L; CD252), linked by a central
Fc domain (PD1-Fc-OX40L), with potential immunostimulatory and antineoplastic activities.
Upon intravenous administration, ARC fusion protein SL-279252 simultaneously binds
to both tumor necrosis factor receptor superfamily member 4 (TNFRSF4; OX40) and PD-1
expressed on T-lymphocytes. Stimulation of OX40 may promote cytokine production and
induce proliferation of memory and effector T-lymphocytes against tumor cells, while
PD-1 binding disrupts PD-1 signaling and may restore immune function through the activation
of T-cells. This may enhance the immune-mediated elimination of tumor cells more effectively
than PD-1 blockade or OX40-agonism alone. OX40L, a cell surface glycoprotein and member
of the tumor necrosis factor (TNF) ligand family, provides a co-stimulatory signal
for the proliferation and survival of activated T-cells. PD-1, a transmembrane protein
in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune
checkpoint that negatively regulates T-cell activation and effector function when
activated by its ligands programmed cell death-1 ligand 1 (PD-L1; CD274) or 2 (PD-L2);
it plays an important role in tumor evasion from host immunity.;
Molecule name : SL 279252; SL-279252;
NCI Metathesaurus CUI : CL970428;
Origin ID : C161803;
UMLS CUI : C5206107;
Semantic type(s)
- concept_is_in_subset
- has_target
