" /> Zeluvalimab - CISMeF





Preferred Label : Zeluvalimab;

NCIt synonyms : Anti-PD-1 Monoclonal Antibody AMG 404;

NCIt definition : A human monoclonal antibody directed against the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, zeluvalimab targets, binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T-cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands, programmed cell death-1 ligand 1 (PD-L1; B7-H1; CD274) and 2 (PD-L2); it plays an important role in tumor evasion from host immunity.;

UNII : DX474PAV6P;

CAS number : 2315361-37-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2315361-37-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AMG 404; AMG-404;

NCI Metathesaurus CUI : CL970132;

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15/05/2024


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