NCIt definition : A monoclonal antibody directed against the cell surface glycoprotein CD52 (CAMPATH-1
antigen; Cambridge pathology 1 antigen), with potential immunodepleting activity.
Upon administration, anti-CD52 monoclonal antibody ALLO-647 selectively targets and
binds to CD52, thereby triggering a host immune response that results in the lysis
of CD52-positive lymphocytes. This leads to immunodepletion and may prevent graft-versus-host
disease (GvHD). CD52 is a glycoprotein expressed on the surface of many immune cells,
including essentially all B- and T-lymphocytes.;
Semantic type(s)