Preferred Label : Avadomide;
NCIt synonyms : 2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-;
NCIt definition : A novel, small molecule cereblon-modulating agent with potential antineoplastic, antiangiogenic
and immunomodulatory activities. Upon oral administration, avadomide binds to and
modulates cereblon to promote recruitment of the hematopoietic transcription factors
Aiolos and Ikaros to the Cullin-4 RING E3 ubiquitin ligase complex. This binding results
in the ubiquitination and rapid proteasomal degradation of Aiolos and Ikaros and the
derepression of interferon (IFN)-stimulated genes, including DDX58 and IRF7, leading
to apoptosis of certain tumor cells. Additionally, Aiolos degredation leads to derepression
of the IL2 gene, thereby enhancing interleukin-2 production, costimulation of T-lymphocytes
and IL-2-induced T-cell proliferation. Avadomide may also promote the activation of
natural killer (NK) cells, potentially enhancing tumor cell killing. Aiolos and Ikaros
are transcriptional repressors known to play an important role in normal B- and T-cell
function.;
UNII : 28DZS29F59;
InChIKey : RSNPAKAFCAAMBH-UHFFFAOYSA-N;
CAS number : 1015474-32-4;
Molecule name : CC 122; CC-122;
NCI Metathesaurus CUI : CL969760;
Origin ID : C160786;
UMLS CUI : C5139930;
Semantic type(s)
- concept_is_in_subset
- has_target
