Preferred Label : Anti-ILT4 Monoclonal Antibody MK-4830;
NCIt synonyms : Anti-leukocyte Immunoglobulin-like Receptor 2 Monoclonal Antibody MK-4830; Anti-LIR2 Monoclonal Antibody MK-4830;
NCIt definition : A human monoclonal antibody directed against the inhibitory immune checkpoint receptor
immunoglobulin-like transcript 4 (ILT4; leukocyte immunoglobulin-like receptor subfamily
B member 2; LILRB2; lymphocyte immunoglobulin-like receptor 2; LIR2; monocyte/macrophage
immunoglobulin-like receptor 10; MIR-10; CD85d), with potential immunomodulating and
antineoplastic activities. Upon administration, anti-ILT4 monoclonal antibody MK-4830
targets and binds to ILT4. This prevents the binding of ILT4 ligands to their receptor
and prevents ILT4-mediated signaling. This abrogates the immunosuppressive activities
of ILT4 in the tumor microenvironment (TME), activates the expression of pro-inflammatory
cytokines, including GM-CSF and tumor necrosis factor alpha (TNFalpha), and enhances
a cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response. ILT4, plays a
key role in tumor immune evasion. ILT4, a transmembrane protein and inhibitory member
of the immunoglobulin-like transcript (ILT) family of proteins, is expressed primarily
by myeloid cells, including monocytes, macrophages, dendritic cells (DCs) and granulocytes,
and certain tumor cells.;
Molecule name : MK 4830; MK-4830;
NCI Metathesaurus CUI : CL969335;
Origin ID : C160204;
UMLS CUI : C5205034;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
