Preferred Label : Safimaltib;
NCIt synonyms : Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1 Inhibitor JNJ-67856633; MALT1 Inhibitor JNJ-67856633; 1-(1-Oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-pyrazole-4-carboxamide;
NCIt definition : An orally bioavailable inhibitor of mucosa-associated lymphoid tissue lymphoma translocation
protein 1 (MALT1), with potential antineoplastic activity. Upon administration, safimaltib
targets, binds to, and prevents the activity of MALT1. This inhibits MALT1-dependent
signaling, reduces interleukin-10 (IL-10) and upregulates interferon (IFN). This results
in the inhibition of Janus kinase/signal transducers and activators of transcription
(JAK/STAT) signaling and nuclear factor-kappa B (NF-kB) signaling, induces apoptosis,
and inhibits tumor cell growth of MALT1-expressing tumor cells. MALT1 belongs to the
caspase family of proteases and is the active component of the CARD11-BCL10-MALT1
(CBM) signaling complex. It plays an essential role in B- and T-lymphocyte activation
and is over-activated in certain tumor cells.;
UNII : L9790S42AI;
CAS number : 2230273-76-2;
Molecule name : JNJ-67856633; JNJ 67856633;
NCI Metathesaurus CUI : CL969161;
Origin ID : C160147;
UMLS CUI : C5706572;
Semantic type(s)
- concept_is_in_subset
- has_target
