Preferred Label : Elbasvir/Grazoprevir;
NCIt synonyms : Elbasvir-Grazoprevir; Grazoprevir-Elbasvir; Grazoprevir/Elbasvir;
NCIt definition : A fixed dose combination of elbasvir, an inhibitor of the hepatitis C virus (HCV)
non-structural protein 5A (NS5A), and grazoprevir, a second-generation inhibitor of
the HCV NS3/4A serine protease, with activity against certain HCV genotypes. Upon
oral administration of elbasvir/grazoprevir, elbasvir inhibits the activity of the
NS5A protein, leading to disruption of the viral RNA replication complex, blockage
of HCV RNA production, and inhibition of viral replication. Grazoprevir inhibits the
NS3/4A serine protease enzyme, thereby disrupting the cleavage of the virally encoded
polyprotein into mature proteins and preventing the formation of the viral replication
complex. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae
family; HCV infection is associated with the development of certain cancers.;
Drug name : Zepatier;
Molecule name : MK-8742/ MK-5172;
ChEBI ID : CHEBI:132973;
Origin ID : C159973;
UMLS CUI : C4080453;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
https://www.has-sante.fr/jcms/p_3478084/fr/zepatier-elbasvir/grazoprevir-hepatite-c-chez-les-adolescents-a-partir-de-12-ans
2024
false
false
false
France
evaluation of the transparency committee
adolescence
Hepatitis C Virus
hepatitis C
viral hepatitis c
Elbasvir/Grazoprevir
adolescent
Zepatier
Autonomic Nervous System
Teenager
Twelve
elbasvir-grazoprevir drug combination
Adolescents
Adolescent
Hepatitis C Infection
Algeria
---
