Preferred Label : Molibresib Besylate;
NCIt synonyms : 2-((4S)-6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepin-4-yl)-N-ethylacetamide
monobenzenesulfonate salt;
NCIt definition : The besylate salt of molibresib, a small molecule inhibitor of the BET (Bromodomain
and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic
activity. Upon administration, molibresib binds to the acetylated lysine recognition
motifs on the bromodomain of BET proteins, thereby preventing the interaction between
the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling
and gene expression. Prevention of the expression of certain growth-promoting genes
may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of
bromodomain at the N-terminus, BET proteins, comprising of BRD2, BRD3, BRD4 and BRDT,
are transcriptional regulators that play an important role during development and
cellular growth.;
UNII : K04D7I4BCH;
InChIKey : UQGMFOYDYUZADE-FERBBOLQSA-N;
CAS number : 1895049-20-3;
Molecule name : GSK525762C;
NCI Metathesaurus CUI : CL969105;
Origin ID : C159943;
UMLS CUI : C5204817;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
