Molibresib - CISMeF

Preferred Label : Molibresib;

NCIt definition : A small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, molibresib binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, BET proteins, comprising of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth.;

UNII : 5QIO6SRZ2R;

InChIKey : AAAQFGUYHFJNHI-SFHVURJKSA-N;

CAS number : 1260907-17-2;

Molecule name : GSK525762; I-BET 762; GSK-525762A;

Details

Origin ID

C101538;

UMLS CUI

C4682384;

Currated CISMeF NLP mapping
- molibresib [MeSH Supplementary Concept]
- molibresib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- molibresib [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Molibresib Besylate [NCIt concept]
has_target
- Bromodomain Testis-Specific Protein [NCIt concept]
- Bromodomain-Containing Protein 2 [NCIt concept]
- Bromodomain-Containing Protein 3 [NCIt concept]
- Bromodomain-Containing Protein 4 [NCIt concept]
is_free_acid_or_base_form_of
- Molibresib Besylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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